Highlights
- Rabeprazole, marketed under the brand name AcipHex, is a proton pump inhibitor used to treat acid-related conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
- The medication works by reducing the production of stomach acid, providing relief from symptoms like heartburn, regurgitation, and difficulty swallowing.
- This medication is only available by prescription and may not be right for some individuals, including children, pregnant or breastfeeding women, elderly patients, or those with certain medical conditions.
- Common side effects may include headache, diarrhea, nausea, and abdominal pain.
- Note that rabeprazole may interact with iron supplements, kinase inhibitors, and other medications.
Gastrointestinal issues cause more than discomfort. More than the occasional indigestion, GI issues can be a sign of a disease that wreaks havoc on your digestive system. These issues can range from mild to serious, and if left untreated, they can lead to worse problems over time. Medications like rabeprazole aim to provide relief from damage caused by digestive issues.
It’s estimated that 60-70 million people in the United States have some form of digestive disease. Symptoms like acid reflux, stomach pain, constipation, diarrhea, and bloating can interfere with activities of daily life. While many of these symptoms are manageable, some can lead to more serious consequences, such as malnutrition or toxin build-up in the body.
Here’s a closer look at rabeprazole, a prescription medication that helps prevent damage caused by acid reflux.
What Is Rabeprazole and What Is It Used For?
Rabeprazole is a prescription medication used to treat the symptoms of GERD. This condition occurs when stomach acid flows backward in the digestive system, affecting the esophagus. By reducing the amount of stomach acid the body produces, the esophagus has less exposure to stomach contents and more time to heal.
Doctors may also prescribe this medication for:
- Zollinger-Ellison syndrome
- Erosive esophagitis
- Duodenal ulcers
Rabeprazole is sold under the brand name AcipHex.
How Does Rabeprazole Work?
Rabeprazole belongs to the drug class of proton pump inhibitors. These drugs reduce stomach acid production, which helps to alleviate heartburn, acid reflux, and stomach ulcers.
Parietal cells in the stomach lining contain proton pumps, which secrete acid into the stomach. Rabeprazole binds to these proton pumps, blocking acid production and reducing the acidity in the stomach.
Rabeprazole’s effects are long-lasting, as the turnover rate of new proton pumps is slow. This allows the patient to enjoy the benefits of the medication even after rabeprazole leaves the body.
Rabeprazole Dosage and Administration
Rabeprazole is typically recommended for short-term use, given the drug’s long-lasting effects (though it may occasionally be prescribed for longer-term problems). It’s available in its generic form and under the brand name AcipHex in 20, 10, and 5 milligram tablets.
Rabeprazole is usually prescribed for one dose per day taken after the morning meal, but specific instructions can vary based on the condition being treated and the patient’s individual needs. For example, this drug might also be used in combination with other medications to treat Helicobacter pylori (H. pylori), and is taken twice per day in this case.
How Should I Take Rabeprazole?
Take rabeprazole whole with a full glass of water. Do not crush, chew, or break the tablets.
Finish all of your medication, even if you’re feeling better. Don’t stop taking this medication without first consulting your doctor. Don’t take it more or less often than your doctor prescribes.
What Are the Potential Side Effects of Rabeprazole (AcipHex)?
Rabeprazole may cause side effects. Common side effects include but are not limited to:
- Headache
- Nausea
- Diarrhea
- Vomiting
- Gas
- Sore throat
- Constipation
- Stomach discomfort
Some patients have reported more serious side effects with this medication. Notify your doctor immediately if you experience any of the following:
- Seizures
- Severe diarrhea with watery stools
- New or worsening joint pain
- Rash, hives, or other signs of an allergic reaction
- Blood in the urine
- More or less frequent urination
- Irregular heartbeat
- Dizziness
Remember, no list of side effects is complete. Discuss side effects with your provider or pharmacist.
What Should I Avoid When Taking Rabeprazole?
Iron supplements may interact with rabeprazole. Let your doctor know if you are taking iron supplements. Do not start taking iron while you’re on rabeprazole without first consulting with your doctor.
If you experience watery stools while taking rabeprazole, do not start taking anti-diarrhea medication before speaking with your doctor. Persistent diarrhea may be a sign of a serious condition known as Clostridium difficile-associated diarrhea, which should be addressed by a healthcare professional.
What Should I Do If I Miss a Dose of Rabeprazole?
It is okay to skip a missed dose of rabeprazole if it is almost time for your next dose. Never double up on doses to make up for a missed dose.
What Should I Do If I Overdose on Rabeprazole?
If you overdose on rabeprazole, seek immediate medical attention. Dial 911 or contact the poison control center at 1-800-222-1222.
What Precautions Should I Take With Rabeprazole (AcipHex)?
Before starting rabeprazole, exercise the following precautions:
- Inform your doctor of any allergies you have. These include allergies to rabeprazole or other proton pump inhibitors (PPIs) such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, or any other medications.
- Discuss all medications and supplements you’re currently taking. Some medications may interact with rabeprazole. Be aware that certain nonprescription or herbal products, such as iron supplements, may interact with this medication. Make sure to seek advice before starting, stopping, or changing any medications while taking rabeprazole.
- Notify your doctor of any known medical conditions. Specifically, tell your doctor if you have or have had low levels of magnesium, calcium, or potassium in your blood, hypoparathyroidism, low vitamin B12 levels, osteoporosis, autoimmune diseases like systemic lupus erythematosus, or liver disease.
- Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Call your doctor if you become pregnant while taking rabeprazole.
Contraindications
Some people should not take rabeprazole. Others should use it with caution under close medical supervision.
Keep in mind that these lists are general guidelines. In special cases, doctors may feel the benefits of taking a particular medication outweigh the risks, so if you are in one of these groups, talk to your doctor about your personal situation.
Who Should Not Take Rabeprazole?
- Patients also taking rilpivirine
- A history of kidney problems or breathing problems
- Allergic to similar medications, such as esomeprazole, pantoprazole, or omeprazole
Who Should Take Rabeprazole With Caution?
- Elderly patients
- Individuals with lupus
- People with osteoporosis or low bone density
- Patients with liver disease
- Pregnant or breastfeeding women
- Children under 12 (certain forms and strengths of rabeprazole are not approved for children)
Are There Any Other Potential Drug Interactions With Rabeprazole (AcipHex)?
According to Drugs.com, a significant number of drugs and supplements can interact with this medication.
The most important potential interactions to be aware of include:
- Dasatinib and other kinase inhibitors. Kinase inhibitors may be rendered less effective.
- Digoxin. Proton pump inhibitors may increase the effects of digoxin.
- Rilpivirine. This may increase the body’s absorption of rilpivirine and render it less effective against HIV.
- Warfarin. This combination may increase the risk of bleeding.
For a list of all known interactions, visit the Drugs.com Drug Interactions Checker. However, no list of potential drug interactions is complete, so let your provider know if you experience any new or unusual symptoms after taking this medication.
Learning How Rabeprazole Affects Your Health
For individuals with GERD, drugs like rabeprazole may provide much-needed relief. GERD symptoms can interfere with daily life, so treating this condition with rabeprazole may make it easier to live a full, productive life.
However, since no medication is without risks and side effects, it’s important to weigh the benefits of rabeprazole with potential downsides.
Now that you know what to consider when taking rabeprazole, your next step is to find your prescription at an affordable price.
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This information is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication.
