Highlights
- Dexlansoprazole is a treatment option for acid-related stomach issues, persistent heartburn, GERD, ulcers, erosive esophagitis, and more.
- Dexlansoprazole, also known by the brand name Dexilant, works by reducing the amount of acid produced in the stomach.
- This medication has a dual-release mechanism for long-lasting relief that allows your stomach and esophagus to heal.
- Dexlansoprazole (Dexilant) is available by prescription only.
Stomach acid is a natural part of digestion, but if your body produces too much, you might be suffering from acid reflux. Conditions like persistent heartburn, gastroesophageal reflux disease (GERD), and erosive esophagitis can be treated by lowering the amount of acid in your stomach. Dexlansoprazole (also known by the brand name Dexilant) is a powerful prescription medication that can give you relief that lasts.
What Is Dexlansoprazole (Dexilant) and What Is It Used For?
Dexlansoprazole is primarily used to treat GERD and other conditions associated with excessive stomach acid, like heartburn and peptic ulcers. This medication belongs to the class of drugs known as proton pump inhibitors (PPIs).
Dexlansoprazole’s off-label uses include treating gastritis (swelling of the stomach lining), Zollinger-Ellison syndrome, and ulcer prevention. It may also help reduce the risk of esophageal cancer, though more research is needed to confirm this.
The term “off-label” means that the FDA has not approved a drug for these conditions, so the medication may or may not be as effective for these unapproved uses.
How Does Dexlansoprazole Work?
Proton pump inhibitors like dexlansoprazole work by binding to enzyme receptors and reducing the amount of acid the stomach can produce. With less acid, GERD symptoms are greatly reduced, and the stomach and esophagus have a chance to heal. Dexlansoprazole has a dual-release formulation that allows it to provide longer-lasting relief than other PPIs.
Dexlansoprazole Dosage and Administration
Dexlansoprazole comes in delayed-release capsules and is typically prescribed in 30 or 60 milligram strengths. The usual dosage is once daily, and the duration of treatment depends on the condition being treated and the individual’s response to the medication.
Note that the dosage regimens above are general guidelines; only a healthcare provider can determine the appropriate dosage for an individual.
How Should I Take Dexlansoprazole?
Always follow your healthcare provider’s recommendations when taking this medication. Most people take dexlansoprazole once per day before meals. Because of dexlansoprazole’s dual-release mechanism, the capsules should be swallowed whole (not chewed or crushed). If you have trouble swallowing due to esophageal damage, your doctor may recommend opening the capsule and sprinkling it on soft foods like applesauce or yogurt.
What Are the Potential Side Effects of Dexlansoprazole?
Like all medications, dexlansoprazole may have side effects. This list is not complete and not everyone experiences the same symptoms, so talk to your doctor or pharmacist about dexlansoprazole and any side effects you experience.
Common Side Effects of Dexlansoprazole
- Headache
- Diarrhea
- Nausea
- Stomach pain
- Gas and bloating
Less Common But More Serious Side Effects of Dexlansoprazole
- Severe allergic reactions, which may include swelling, difficulty breathing, itching, or dizziness
- Kidney problems
- Bone fractures (with long-term use)
- Signs of a vitamin B12 deficiency
What Should I Avoid When Taking Dexlansoprazole?
While taking dexlansoprazole, it’s important to follow your healthcare provider’s recommendations and avoid certain activities and medications.
- Avoid taking dexlansoprazole with drugs that contain rilpivirine.
- Limit or avoid alcohol because it can worsen symptoms and affect the way this medication works.
- Dexlansoprazole reduces stomach acid and can improve the esophagus and stomach lining, but you should follow a diet that’s easy on your stomach. Be careful when eating foods that are known to cause reflux symptoms.
What Should I Do If I Miss a Dose of Dexlansoprazole?
If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. In that case, skip the missed dose and resume your regular schedule. Do not take an extra dose to make up for a missed one.
What Should I Do If I Overdose on Dexlansoprazole?
Symptoms of an overdose may include confusion, drowsiness, blurry vision, fast heartbeat, nausea, sweating, headache, and dry mouth. If you suspect an overdose, seek immediate medical attention or contact your local poison control center.
What Precautions Should I Take With Dexlansoprazole?
Before taking this medication, speak to your doctor about dexlansoprazole’s effects and follow these special precautions:
- Allergy warning. Tell your doctor about any allergies to dexlansoprazole and other medications.
- Medication review. Before taking dexlansoprazole, talk to your doctor about all your medications, including prescriptions, over-the-counter medications, herbal products, vitamins, and supplements. Always ask your doctor before starting, stopping, or changing your medications while taking dexlansoprazole.
- Health history review. Discuss your health history and be sure to mention if you’ve had any issues with low magnesium, calcium, potassium, sodium, or vitamin B12. Mention any history of hypoparathyroidism, osteoporosis, autoimmune diseases, or liver disease.
- Pregnancy and breastfeeding. PPIs may be safe to take during pregnancy, but it’s important to tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant because you may need to adjust your dosage.
- Age-related risks. This medication may not be right for people under the age of 2 or over the age of 70. Talk to your doctor about age-related risks and follow the recommended duration of treatment.
Contraindications of Dexlansoprazole
Some people should not take dexlansoprazole. Others should use it with caution under close medical supervision.
Keep in mind that these lists are general guidelines. In special cases, doctors may feel the benefits of taking a particular medication outweigh the risks, so if you are in one of these groups, talk to your doctor about your personal situation.
Who Should Not Take Dexlansoprazole?
- Individuals who are allergic to dexlansoprazole or any other PPI
- People taking HIV medications that include rilpivirine
- People with a history of severe liver disease (though those with mild liver disease may still take it under supervision)
Who Should Take Dexlansoprazole With Caution?
- Patients with certain medical conditions, such as hypomagnesemia (low magnesium) or vitamin B12 deficiency
- Older adults and people with impaired kidney function, as they may be more susceptible to certain side effects
- People with autoimmune diseases, including lupus
- People with bone diseases or broken bones, because this drug class may affect bone density
Are There Any Other Potential Drug Interactions With Dexlansoprazole?
According to Drugs.com, a significant number of drugs and supplements can interact with this medication.
Dexlansoprazole changes the pH of the stomach acid, which may change the way certain drugs are absorbed and make them less effective. The most important potential interactions to be aware of include:
- Antiviral medications like atazanavir, nelfinavir, and rilpivirine
- Immunosuppressants including tacrolimus
- Chemotherapy drugs including methotrexate
- Cancer medications like erlotinib and gefitinib
For the complete known interactions list, visit the Drugs.com Drug Interactions Checker. However, no list of potential drug interactions is complete, so double-check with your provider and let them know if you experience any new or unusual symptoms after taking this medication. 
Dexlansoprazole Can Soothe Your Stomach and Promote Healing
If excess acid is damaging your esophagus and stomach, PPIs like dexlansoprazole can improve the pH so you can heal. This powerful medication can provide long-lasting relief, but it’s important to understand its uses, side effects, and how it interacts with other medications. If your doctor has prescribed dexlansoprazole for relief and recovery, you can find the best prices for your medications with BidRx.
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This information is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication.
