Highlights
- Lisinopril/HCTZ is a prescription medication used to treat hypertension (high blood pressure).
- This medication is a combination of two medications that work together to control high blood pressure.
- Lisinopril/HCTZ is available in three strengths in tablet form, which is usually taken once daily.
- Possible side effects include lightheadedness, dizziness, fatigue, headache, diarrhea, and body aches, among others.
- Individuals who are pregnant, planning to become pregnant, breastfeeding, or have kidney disease or diabetes may not be candidates for lisinopril/HCTZ.
High blood pressure is a common problem — nearly half of Americans over the age of 20 experience high blood pressure. Because high blood pressure is a contributing factor to stroke, heart attack, kidney problems, and heart disease, some individuals may benefit from a prescription medication like lisinopril/hydrochlorothiazide (HCTZ) that improves blood pressure.
Here’s what patients should know about lisinopril/HCTZ, including its purpose, how it works, its formulas, dosages, side effects, risks, and other helpful information.
What Is Lisinopril/HCTZ and What Is It Used For?
Lisinopril/HCTZ is a combination of two medications used to treat hypertension (high blood pressure). This combination is designed to give patients more effective treatment when single medications prove ineffective.
Lisinopril/HCTZ is available in its generic form as well as under the brand names Prinzide and Zestoretic.
How Does Lisinopril/HCTZ Work?
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that prevents the body from producing angiotensin II, an enzyme that narrows the blood vessels. Lisinopril widens and relaxes the blood vessels to improve flow and reduce blood pressure.
Hydrochlorothiazide is a thiazide diuretic, which helps the body eliminate excess water and salt through urine. This process helps to reduce the body’s blood volume, which also helps to reduce blood pressure.
What Formulas Are Available for Lisinopril/HCTZ?
Lisinopril/HCTZ is available as an oral tablet in three strengths:
- 10 milligram/12.5 milligram, which contains 10 milligrams of lisinopril and 12.5 milligrams of HCTZ
- 20 milligram/12.5 milligram
- 20 milligram/25 milligram
Your doctor may adjust your prescription based on your body’s response to the medication.
Lisinopril/HCTZ Dosage and Administration
Dosage and administration can vary by patient. It’s important to follow your doctor’s directions for this medication to mitigate side effects and maximize its effectiveness. The following is general information on dosage and administration.
Adults
- A typical starting dose is one 10 milligram/12.5 milligram tablet by mouth every day, but individual prescriptions may vary. Always follow your provider’s instructions.
- Take this medication at the same time every day.
- Your doctor may adjust your dose strength and frequency as needed.
- If this medication causes you to urinate more frequently, take it at least four to six hours before bedtime.
Children
Use and dosage requirements will vary; consult your pediatrician for specific directions.
How Should I Take Lisinopril/HCTZ?
Proper usage of lisinopril/HCTZ allows you to get the maximum benefit from this medication. Follow these guidelines for safe and proper use:
- Take this medication by mouth once daily, with or without food.
- Swallow the tablet whole; never crush, chew, or break the tablet.
- Drink plenty of fluids while taking lisinopril/HCTZ.
- Do not take more or less of this medication than your doctor prescribes.
- Do not share this medicine with others.
- Do not stop taking this medicine without first consulting with your doctor.
Your doctor may have other specific instructions for taking lisinopril/HCTZ. Let your provider know if you have any questions or concerns before taking this medication.
What Are the Potential Side Effects of Lisinopril/HCTZ?
Common side effects associated with lisinopril/HCTZ include but are not limited to:
- Body aches or pain
- Cough
- Diarrhea
- Dizziness
- Fatigue
- Headache
- Heartburn
- Nausea
- Sneezing
- Sore throat
- Sweating
- Tingling, pain, or burning in the hands and feet
- Upset stomach
- Vomiting
- Decreased libido, usually temporary
Less-common but serious side effects may include:
- Chest pain
- Decreased urination
- Fever
- Low blood pressure (hypotension)
- Rash
- Shortness of breath
- Stomach pain
- Swelling of the hands, lips, face, tongue, or throat
Additional side effects may occur. Report any new or unusual symptoms to your provider.
What Should I Avoid When Taking Lisinopril/HCTZ?
Following are precautions you should take while you’re on this medication.
- Alcohol, narcotic pain medications, and sleeping pills may increase feelings of dizziness or lightheadedness when taking lisinopril/HCTZ.
- Avoid sun exposure (including tanning beds), as this medication may increase the risk of skin cancer. Use sunscreen and wear protective clothing outdoors.
- Unless instructed by your doctor, do not take potassium supplements or salt substitutes while taking this medication.
- Make sure you drink plenty of fluids when outdoors, exercising, or during hot weather. However, drinking too much water can cause adverse effects. Consult with your doctor regarding the recommended liquid intake for you.
What Should I Do If I Miss a Dose of Lisinopril/HCTZ?
If you skip a dose, take the dose as soon as possible unless it is almost time for your next dose. Never take a double dose to make up for a missed dose. It’s helpful to take your medication at the same time each day to avoid forgetting or missing doses.
What Should I Do If I Overdose on Lisinopril/HCTZ?
Overdosing on lisinopril/HCTZ can lead to serious health issues and should be treated as a medical emergency. Seek immediate medical attention. You may also call Poison Control at 1-800-222-1222.
Who Should Not Take Lisinopril/HCTZ?
People in the following groups should not take lisinopril/HCTZ:
- Women who are pregnant should not take lisinopril/HCTZ, as this medication may damage the fetus.
- Patients who have diabetes or kidney disease and are also taking a medication containing aliskiren may not be a candidate for lisinopril/HCTZ. If you are taking aliskiren for a reason other than high blood pressure, you should talk to your doctor about whether it is safe for you to take lisinopril/HCTZ.
Drugs.com lists a total of 19 disease interactions for this medication, ranging from moderate to major. Please check the list and be sure your provider knows if you have one of these conditions.
Are There Any Potential Drug Interactions With Lisinopril/HCTZ?
Lisinopril/HCTZ may not be safe for patients taking the following medications:
- Lithium
- Other blood pressure medications
- Aliskiren
- Dofetilide
- Sacubitril
A total of 596 medications can interact with lisinopril/HCTZ, categorized as moderate or minor. Please see the Drug Interactions Checker for the complete list.
Tell all your providers about all the medications you’re currently taking, including vitamins and herbal supplements.
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Please note that this information is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication.
