{"id":1531,"date":"2024-01-05T13:05:35","date_gmt":"2024-01-05T13:05:35","guid":{"rendered":"https:\/\/www.bidrx.com\/blog\/?p=1531"},"modified":"2024-01-04T19:07:01","modified_gmt":"2024-01-04T19:07:01","slug":"guide-to-benzodiazepines","status":"publish","type":"post","link":"https:\/\/www.bidrx.com\/blog\/anxiety-medications\/guide-to-benzodiazepines\/","title":{"rendered":"Reference Guide to Benzodiazepines"},"content":{"rendered":"<p><b>Highlights\u00a0<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Benzodiazepines are common prescription medications used to treat anxiety, insomnia, seizures, alcohol withdrawal, and muscle spasms.<\/b><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>These medications come in three sub-types: short-acting, intermediate-acting, and long-acting.<\/b><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Benzodiazepines carry a risk of dependency and abuse, so it\u2019s essential to use these medications as directed and under a doctor\u2019s supervision.<\/b><\/li>\n<\/ul>\n<hr \/>\n<p><span style=\"font-weight: 400;\">Anxiety is a normal part of life. Most people worry, but when anxiety becomes a daily part of life \u2014 even if there\u2019s no obvious reason for it \u2014 it might be time to speak to your doctor.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s estimated that <\/span><a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/anxiety-disorders\"><span style=\"font-weight: 400;\">more than 300 million people worldwide<\/span><\/a><span style=\"font-weight: 400;\"> experience anxiety disorders. They\u2019re the most common type of mental disorder and can be highly treatable.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Benzodiazepines are one option to treat anxiety and other conditions. Let\u2019s explore in more detail what benzodiazepines are, how they work, the different types, side effects, and other helpful information so you can work with your doctor to make an informed decision.<\/span><\/p>\n<h2>What Are Benzodiazepines?<\/h2>\n<p><span style=\"font-weight: 400;\">Benzodiazepines (also known as \u201cbenzos\u201d) are a type of medication that promotes relaxation. Some conditions they\u2019re used to treat include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety disorders<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle spasms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alcohol withdrawal<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These medications slow down the central nervous system. With less stimulation, the brain can relax and make a person feel less anxious.\u00a0<\/span><\/p>\n<h2>How Do Benzodiazepines Work?<\/h2>\n<p><span style=\"font-weight: 400;\">Benzodiazepines enhance the activity of the neurotransmitter <\/span><a href=\"https:\/\/mhanational.org\/what-gaba\"><span style=\"font-weight: 400;\">gamma-aminobutyric acid<\/span><\/a><span style=\"font-weight: 400;\">, or GABA. GABA is a natural chemical in the brain that slows down nerve activity.<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1533\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2024\/01\/anxoious-young-woman-in-need-of-benzodiazepines.jpg\" alt=\"anxious young woman in need of benzodiazepines\" width=\"780\" height=\"520\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Benzodiazepines bind to specific receptors in the brain that are sensitive to GABA. This helps to make it easier for GABA to bind to these receptors. As a result, benzodiazepines boost the calming effect of GABA on nerve cells. These cells become less excited, creating a sedative effect.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Individuals taking benzodiazepines may find it easier to sleep and feel less anxious.\u00a0<\/span><\/p>\n<h2>Benzodiazepine Differences and Similarities<\/h2>\n<p><span style=\"font-weight: 400;\">Benzodiazepines are classified by their duration of action \u2014 short-acting, intermediate-acting, and long-acting.\u00a0<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Medication<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Indication<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Onset of Action<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Duration of Action<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">midazolam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Sedation, anesthesia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rapid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Short<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">triazolam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rapid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Short<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">alprazolam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anxiety, panic disorders<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rapid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">lorazepam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anxiety, seizures\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rapid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">oxazepam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anxiety, alcohol withdrawal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rapid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">temazepam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">clonazepam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Epilepsy, panic disorders<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">chlordiazepoxide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anxiety, alcohol withdrawal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">diazepam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anxiety, seizures\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intermediate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">flurazepam<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">While side effects, drug interactions, and warnings and indications are similar among the three subtypes, key differences include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Duration of effects: <\/b><span style=\"font-weight: 400;\">Short-acting benzodiazepines wear off more quickly, making them suitable for short-term or as-needed use, while intermediate- and long-acting forms have more prolonged effects, making them suitable for longer-term management of conditions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Risk of dependence and withdrawal: <\/b><span style=\"font-weight: 400;\">Generally, the shorter the action, the quicker the body adjusts to and depends on the effects, leading to potential withdrawal symptoms when the medication is stopped. Intermediate- and long-acting forms may be associated with more gradual withdrawal.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Usage patterns:<\/b><span style=\"font-weight: 400;\"> Short-acting types are often used for acute management of anxiety or sleep issues, while longer-acting types may be preferred for chronic management due to their sustained effects.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">There are also similarities among the three subtypes, including:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Common side effects: <\/b><span style=\"font-weight: 400;\">Side effects across all types include sedation, motor impairment, cognitive impairment, dependence, and withdrawal symptoms.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Adjusting for individual needs:<\/b><span style=\"font-weight: 400;\"> The choice among the subtypes often depends on the patient&#8217;s individual health status, the specific condition being treated, and personal history, including the risk of abuse or dependency.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monitoring: <\/b><span style=\"font-weight: 400;\">Regardless of the subtype, it&#8217;s crucial to monitor for side effects, effectiveness, and any signs of dependency or withdrawal, adjusting the treatment plan as necessary.<\/span><\/li>\n<\/ul>\n<h2>Short-Acting Benzodiazepines<\/h2>\n<p><span style=\"font-weight: 400;\">Short-acting benzodiazepines have a brief duration of action, providing a rapid onset after ingestion and quicker relief of symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">They also have a shorter half-life, which means they are metabolized and eliminated from the body more quickly. This also means they are effective for a shorter period of time before their effects wear off.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because they wear off more quickly, you may need to take short-acting benzodiazepines more often to maintain their effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common examples of short-acting benzodiazepines include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.drugs.com\/mtm\/triazolam.html\"><span style=\"font-weight: 400;\">triazolam<\/span><\/a><span style=\"font-weight: 400;\"> (Halcion): Often used for short-term treatment of severe insomnia.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.drugs.com\/mtm\/midazolam.html\"><span style=\"font-weight: 400;\">midazolam<\/span><\/a><span style=\"font-weight: 400;\"> (Versed): Commonly used in anesthesia for its sedative and anxiolytic properties.<\/span><\/li>\n<\/ul>\n<h3>Warnings and Contraindications \u2014 Short-Acting Benzodiazepines<\/h3>\n<p><span style=\"font-weight: 400;\">While helpful in managing certain conditions, all benzodiazepines come with warnings and considerations. Warnings and contraindications may vary by medication, so it\u2019s essential to explore these with your healthcare provider before taking any new medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Short-term benzodiazepines may be more contraindicated in situations requiring sustained alertness and coordination due to the rapid onset of sedation.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The following warnings and contraindications also apply to short-acting benzodiazepines:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Respiratory depression. <\/b><span style=\"font-weight: 400;\">These medications can depress respiratory function, especially when combined with other CNS depressants, and are risky for individuals with respiratory disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dependence and withdrawal. <\/b><span style=\"font-weight: 400;\">There is a significant risk of physical dependence and withdrawal symptoms, which can be severe, including anxiety, agitation, and, in extreme cases, seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Abuse potential. <\/b><span style=\"font-weight: 400;\">Due to their quick and potent effects, there&#8217;s a high risk for abuse and misuse, especially in individuals with a history of substance abuse.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy and breastfeeding. Generally contraindicated or used with extreme caution during pregnancy and breastfeeding due to potential adverse effects on the fetus or infant.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Elderly or debilitated patients. <\/b><span style=\"font-weight: 400;\">Increased sensitivity to the sedative and motor impairing effects, leading to a higher risk of falls and cognitive impairment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Psychiatric conditions. Use with caution in individuals with a history of depression or other psychiatric conditions as they can exacerbate symptoms.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Acute narrow-angle glaucoma. <\/b><span style=\"font-weight: 400;\">Typically contraindicated in patients with acute narrow-angle glaucoma due to the risk of increasing intraocular pressure.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Severe hepatic impairment. <\/b><span style=\"font-weight: 400;\">Use with caution or avoid in patients with significant liver disease as it can affect the metabolism and clearance of the medication, leading to increased effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Operating machinery. <\/b><span style=\"font-weight: 400;\">Impaired motor coordination and drowsiness may affect the ability to drive or operate machinery safely.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Alcohol and drug interactions. <\/b><span style=\"font-weight: 400;\">Enhanced effects and potentially dangerous interactions when combined with alcohol, opioids, or other drugs that depress the central nervous system.<\/span><\/li>\n<\/ul>\n<h3>Side Effects \u2014Short-Acting Benzodiazepines<\/h3>\n<p><span style=\"font-weight: 400;\">In general, compared to intermediate- and long-acting benzodiazepines, short-acting medications have:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">More pronounced sedation and drowsiness due to rapid onset.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A higher risk of rebound anxiety and insomnia when they\u2019re discontinued.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased potential for memory impairment and psychomotor impairment, affecting activities like driving.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Side effects of short-acting benzodiazepines may vary by medication and by dosage, but be on the lookout for these potential adverse reactions:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drowsiness and sedation. <\/b><span style=\"font-weight: 400;\">One of the most common side effects, leading to impaired alertness and coordination. This can affect activities such as driving and operating machinery.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cognitive impairment. <\/b><span style=\"font-weight: 400;\">Short-term use can impair memory and learning, a condition often referred to as &#8220;benzo fog,&#8221; affecting concentration and mental clarity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Motor coordination impairment. <\/b><span style=\"font-weight: 400;\">Users may experience a decrease in motor coordination, resulting in clumsiness or unsteady gait, increasing the risk of falls, especially in the elderly.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dependence and withdrawal. <\/b><span style=\"font-weight: 400;\">Even short-term use can lead to physical dependence. Abrupt cessation or reduction in dosage can lead to withdrawal symptoms, which can be severe, including anxiety, agitation, and in rare cases, seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Increased risk of accidents. <\/b><span style=\"font-weight: 400;\">Due to the sedative effects, there&#8217;s an increased risk of accidents and injuries, particularly falls in the elderly.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Respiratory depression. <\/b><span style=\"font-weight: 400;\">Especially in higher doses or when combined with other central nervous system depressants, it can lead to slowed breathing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Paradoxical reactions. <\/b><span style=\"font-weight: 400;\">Some individuals may experience increased anxiety, agitation, aggression, or hallucinations, opposite to the calming effect typically sought.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tolerance. <\/b><span style=\"font-weight: 400;\">Over time, users may require larger doses to achieve the same therapeutic effect, leading to higher risk of side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Gastrointestinal issues. <\/b><span style=\"font-weight: 400;\">Some may experience nausea, constipation, or other digestive discomfort.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Mood changes. <\/b><span style=\"font-weight: 400;\">Depression or mood swings may occur, especially in individuals with a history of these conditions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Allergic reactions. <\/b><span style=\"font-weight: 400;\">Severe allergic reactions can also occur and require immediate medical attention. These include symptoms such as:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Tongue or throat swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">For information about the specific drug you\u2019re taking, visit Drugs.com and search for your medication, or refer to the medication labeling included with your prescription.\u00a0<\/span><\/p>\n<h3>Drug Interactions \u2014Short-Acting Benzodiazepines<\/h3>\n<p><span style=\"font-weight: 400;\">Short-acting benzodiazepines can interact with various drugs, potentially altering their effects or increasing side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Compared to the other benzodiazepines, rapid onset increases the risks of severe interactions with alcohol, opioids, or other sedatives, leading to acute respiratory depression or profound sedation.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Following is a list of potential interactions for short-acting benzodiazepines, but again, be aware that potential interactions will vary by medication and dosage.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Central nervous system (CNS) depressants: <\/b><span style=\"font-weight: 400;\">Concurrent use with other CNS depressants such as alcohol, opioids, other benzodiazepines, or sleep medications can lead to enhanced sedation, respiratory depression, and increased risk of overdose.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Anticonvulsants: <\/b><span style=\"font-weight: 400;\">Some anticonvulsants can affect the metabolism of benzodiazepines, either increasing toxicity or decreasing efficacy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antidepressants: <\/b><span style=\"font-weight: 400;\">Certain antidepressants may increase sedative effects or impact the metabolism of benzodiazepines.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antifungal agents: <\/b><span style=\"font-weight: 400;\">Some antifungal medications, especially azole antifungals, can inhibit the metabolism of benzodiazepines, leading to increased blood levels and prolonged effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cimetidine: <\/b><span style=\"font-weight: 400;\">This heartburn medication can decrease the metabolism of benzodiazepines, increasing their duration and intensity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Oral contraceptives:<\/b><span style=\"font-weight: 400;\"> Can slow down the elimination of benzodiazepines, leading to increased effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Protease inhibitors: <\/b><span style=\"font-weight: 400;\">Used in HIV treatment, these can increase benzodiazepine levels by inhibiting their metabolism.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Smoking:<\/b><span style=\"font-weight: 400;\"> Cigarette smoking can decrease the effectiveness of benzodiazepines due to the induction of certain liver enzymes that metabolize the drugs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Grapefruit juice:<\/b><span style=\"font-weight: 400;\"> Can increase the blood levels of certain benzodiazepines, intensifying their effects and side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Herbal products: <\/b><span style=\"font-weight: 400;\">Some herbs, like St. John&#8217;s Wort, can affect the metabolism of benzodiazepines, while others like kava and valerian may increase sedative effects.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Refer to the Drugs.com <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/triazolam-index.html\"><span style=\"font-weight: 400;\">Drug Interaction Checker<\/span><\/a><span style=\"font-weight: 400;\"> for the complete list of known interactions for the medication you\u2019re taking or considering.<\/span><\/p>\n<h2>Intermediate-Acting Benzodiazepines<\/h2>\n<p><span style=\"font-weight: 400;\">Intermediate-acting benzodiazepines last longer than short-acting benzodiazepines and have a longer half-life. They stay in the body longer, and their effects take longer to wear off.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Medications in this subtype are often prescribed for patients who need a balance between onset and duration of action.<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1534\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2024\/01\/bottle-of-xanax.jpg\" alt=\"bottle of xanax\" width=\"780\" height=\"520\" \/><\/p>\n<p><span style=\"font-weight: 400;\">They\u2019re typically prescribed for conditions that require longer-lasting relief, such as generalized anxiety disorder, muscle spasms, or certain types of seizures. They can also be used for short-term relief of insomnia or sleep disturbances.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Commonly prescribed intermediate-acting benzodiazepines include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.bidrx.com\/home\/medicine_details\/alprazolam-1-mg-tablet\"><span style=\"font-weight: 400;\">alprazolam<\/span><\/a><span style=\"font-weight: 400;\"> (Xanax): Used for anxiety and panic disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.drugs.com\/lorazepam.html\"><span style=\"font-weight: 400;\">lorazepam<\/span><\/a><span style=\"font-weight: 400;\"> (Ativan): Prescribed for anxiety disorders and as a pre-anesthetic.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.drugs.com\/temazepam.html\"><span style=\"font-weight: 400;\">temazepam<\/span><\/a><span style=\"font-weight: 400;\"> (Restoril): Used for the short-term treatment of insomnia.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.drugs.com\/mtm\/oxazepam.html\"><span style=\"font-weight: 400;\">oxazepam<\/span><\/a><span style=\"font-weight: 400;\"> (Serax): Often prescribed for anxiety and alcohol withdrawal.<\/span><\/li>\n<\/ul>\n<h3>Warnings and Contraindications \u2014 Intermediate-Acting Benzodiazepines<\/h3>\n<p><span style=\"font-weight: 400;\">Similar to short-acting medications, the warnings and contraindications of intermediate-acting benzodiazepines can vary by medication and dosage. Interactions may be more prolonged or moderate in intensity compared to short-acting varieties, requiring careful monitoring.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s a general list of warnings to discuss with your provider:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Respiratory depression. <\/b><span style=\"font-weight: 400;\">Patients with respiratory conditions like COPD or sleep apnea should use caution, as benzodiazepines may worsen respiratory function.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Substance abuse history.<\/b><span style=\"font-weight: 400;\"> These medications are not recommended for individuals with a history of substance abuse due to the high potential for dependence and addiction.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pregnancy and nursing.<\/b><span style=\"font-weight: 400;\"> Generally contraindicated during pregnancy and nursing because of the risk of harm to the fetus or nursing infant.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Elderly patients. <\/b><span style=\"font-weight: 400;\">Older adults are at increased risk of cognitive impairment, falls, and other accidents, necessitating careful use and often dose adjustments.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Psychiatric conditions.<\/b><span style=\"font-weight: 400;\"> Those with a history of depression or other psychiatric conditions should use benzodiazepines cautiously, as they can exacerbate certain symptoms.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Acute narrow-angle glaucoma. <\/b><span style=\"font-weight: 400;\">These drugs are contraindicated in individuals with this condition but may be used with caution in those with open-angle glaucoma.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Severe liver impairment.<\/b><span style=\"font-weight: 400;\"> Those with significant liver disease should avoid or use benzodiazepines cautiously due to the risk of increased toxicity and impaired metabolism.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Operating machinery. <\/b><span style=\"font-weight: 400;\">Due to the impairment of cognitive and motor functions, users should be cautious when driving or operating heavy machinery.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Alcohol and other CNS depressants.<\/b><span style=\"font-weight: 400;\"> Using benzodiazepines with other central nervous system depressants can lead to severe sedation or more serious complications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Withdrawal and tolerance. <\/b><span style=\"font-weight: 400;\">There&#8217;s a risk of developing tolerance and dependence, particularly with prolonged use, and withdrawal should be managed carefully.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Allergic reactions.<\/b><span style=\"font-weight: 400;\"> Individuals known to be hypersensitive to benzodiazepines should not use them.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Consult with your doctor for a complete overview of warnings and contraindications before starting any new medication.<\/span><\/p>\n<h3>Side Effects \u2014 Intermediate-Acting Benzodiazepines<\/h3>\n<p><span style=\"font-weight: 400;\">Compared to short-acting benzodiazepines, intermediate-acting types:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tend to cause a moderate level of sedation, usually with a smoother onset and offset.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a lower risk of rebound effects compared to short-acting types, though they\u2019re still present.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a potentially less-abrupt risk of cognitive and motor impairment.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Intermediate-acting types can have mild to serious side effects, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drowsiness and sedation. <\/b><span style=\"font-weight: 400;\">These medications often lead to feelings of tiredness and can significantly impair alertness and coordination.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cognitive impairment. <\/b><span style=\"font-weight: 400;\">Users might experience difficulties with memory, attention, and problem-solving, affecting daily activities and responsibilities.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Motor coordination issues. <\/b><span style=\"font-weight: 400;\">There might be an increased risk of falls and other accidents due to impaired balance and coordination, especially in older adults.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dependence and withdrawal. <\/b><span style=\"font-weight: 400;\">Regular use can lead to physical dependence, and sudden discontinuation can result in withdrawal symptoms, which can be severe.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Respiratory depression. <\/b><span style=\"font-weight: 400;\">In some cases, especially when taken with other depressants, these drugs can slow down breathing, which can be dangerous.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tolerance. <\/b><span style=\"font-weight: 400;\">Over time, users may need higher doses to achieve the same effect, leading to more pronounced side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Mood changes. <\/b><span style=\"font-weight: 400;\">Some individuals might experience alterations in mood, including increased anxiety or depression.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Gastrointestinal disturbances. <\/b><span style=\"font-weight: 400;\">Nausea, vomiting, or constipation may occur, affecting one&#8217;s comfort and appetite.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Paradoxical reactions. <\/b><span style=\"font-weight: 400;\">A small percentage of users might experience the opposite of the intended calming effects, such as increased anxiety or aggression.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Amnesic effects. <\/b><span style=\"font-weight: 400;\">Particularly at higher doses, these drugs can cause difficulties in forming new memories, known as anterograde amnesia.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Let your doctor know of any new or unusual symptoms you notice after beginning any benzodiazepine.\u00a0<\/span><\/p>\n<h3>Drug Interactions \u2014 Intermediate-Acting Benzodiazepines<\/h3>\n<p><span style=\"font-weight: 400;\">Drug interactions with intermediate-acting benzodiazepines are similar to those for short-acting benzodiazepines. However, they may be more prolonged or moderate in intensity compared to short-acting varieties, requiring more careful monitoring.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s the list of known interactions for the intermediate-acting types:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Central nervous system depressants. <\/b><span style=\"font-weight: 400;\">Using benzodiazepines with other CNS depressants like alcohol, opioids, or sedatives can significantly increase sedation, respiratory depression, and the risk of overdose.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Anticonvulsants. <\/b><span style=\"font-weight: 400;\">Some anticonvulsants affect how benzodiazepines are metabolized, potentially changing their effectiveness or side effect profile.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antidepressants. <\/b><span style=\"font-weight: 400;\">Certain antidepressants might interact with benzodiazepines, increasing sedation or affecting how the body processes the benzodiazepines.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antifungal agents.<\/b><span style=\"font-weight: 400;\"> Azole antifungals, in particular, can inhibit the metabolism of benzodiazepines, leading to higher blood levels and prolonged effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cimetidine. <\/b><span style=\"font-weight: 400;\">Commonly used for acid reflux, cimetidine can decrease the metabolism of benzodiazepines, increasing their duration and intensity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Oral contraceptives. <\/b><span style=\"font-weight: 400;\">These may slow the elimination of benzodiazepines from the body, potentially leading to prolonged effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Protease inhibitors.<\/b><span style=\"font-weight: 400;\"> Often used in HIV therapy, these can increase the levels of benzodiazepines by inhibiting their metabolism.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Smoking. <\/b><span style=\"font-weight: 400;\">Cigarette smoking may decrease the effectiveness of benzodiazepines due to increased metabolism by certain liver enzymes.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Get a complete list of known potential interactions for your specific medication with the Drugs.com <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/alprazolam-index.html\"><span style=\"font-weight: 400;\">Drug Interaction Checker<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2>Long-Acting Benzodiazepines<\/h2>\n<p><span style=\"font-weight: 400;\">Long-acting benzodiazepines have an extended duration of action compared to short-acting and intermediate-acting benzodiazepines. They\u2019re typically prescribed to treat conditions that require continuous and prolonged management.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Due to their prolonged effect, there&#8217;s an extended risk of interaction with CNS depressants over a longer period. There may also be increased interaction with medications that affect liver enzymes due to the extended metabolism.<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1535\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2024\/01\/diazepam-tablets.jpg\" alt=\"diazepam tablets\" width=\"780\" height=\"520\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Doctors typically prescribe long-acting benzodiazepines with caution. Because these medications stay in the body for longer, they may carry a higher risk of dependence and withdrawal symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Doctors will monitor you closely while on these medications to minimize potential risks and side effects. Long-term use is usually discouraged.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of long-acting benzodiazepines include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.bidrx.com\/home\/medicine_details\/diazepam-10-mg-tablet\"><span style=\"font-weight: 400;\">Diazepam<\/span><\/a><span style=\"font-weight: 400;\"> (Valium): Used for a range of conditions including anxiety, muscle spasms, and seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.bidrx.com\/home\/medicine_details\/clonazepam-0.25-mg-odt\"><span style=\"font-weight: 400;\">Clonazepam<\/span><\/a><span style=\"font-weight: 400;\"> (Klonopin): Primarily for seizure disorders and panic disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.drugs.com\/mtm\/chlordiazepoxide.html\"><span style=\"font-weight: 400;\">Chlordiazepoxide<\/span><\/a><span style=\"font-weight: 400;\"> (Librium): Often used in alcohol withdrawal and anxiety disorders.<\/span><\/li>\n<\/ul>\n<h3>Warnings and Contraindications \u2014 [Long-Acting Benzodiazepines]<\/h3>\n<p><span style=\"font-weight: 400;\">Warnings and contraindications for long-acting benzodiazepines will vary by medication. Generally speaking, long-acting benzodiazepines carry a greater risk of dependency and should be used with caution.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other warnings may be medication-specific. For example, diazepam is contraindicated in the following individuals:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Known hypersensitivity to diazepam or its ingredients<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients under 6 months of age<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Myasthenia gravis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe respiratory insufficiency<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe hepatic insufficiency<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep apnea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acute narrow-angle glaucoma<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Taking diazepam with other sedatives can cause dangerous side effects or death. Consult with your doctor prior to taking any muscle relaxers, over-the-counter sleep aids, or other medications for anxiety or seizures.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Concomitant use of diazepam with opioids is discouraged and should be used only for patients who do not respond to alternative treatments.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0It is not recommended to drink alcohol while taking diazepam since this medication depresses the central nervous system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Abrupt withdrawal from diazepam could create a temporary increase in the risk of seizures, both in frequency and severity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Women who are pregnant or plan to become pregnant should know that taking diazepam could have negative effects on the developing fetus. Diazepam may also pass into the breastmilk, so it\u2019s not recommended if breastfeeding.<\/span><\/p>\n<h3>Side Effects \u2014 [Long-Acting Benzodiazepines]<\/h3>\n<p><span style=\"font-weight: 400;\">Side effects with long-acting benzodiazepines are common and may vary between medications and dosages. The most commonly reported side effects of diazepam are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ataxia<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Individuals have also reported the following adverse effects:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slurred speech<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vertigo<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypotension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tremors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dysarthria<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stimulation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep disturbances<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle spasms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in libido<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">There have also been reports of falls and fractures in individuals taking benzodiazepines, with the risk increasing in those who take other sedatives and the elderly.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is not a complete list of side effects, and these side effects may vary from person to person.<\/span><\/p>\n<h3>Drug Interactions \u2014 [Long-Acting Benzodiazepines]<\/h3>\n<p><span style=\"font-weight: 400;\">Long-acting benzodiazepines may interact with other drugs, such as the drug types listed for short-acting benzodiazepines. For example, there are 515 known drug interactions with diazepam. Use the <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/diazepam-index.html\"><span style=\"font-weight: 400;\">Drug Interaction Checker<\/span><\/a><span style=\"font-weight: 400;\"> for a complete list.<\/span><\/p>\n<h2>Exploring Benzodiazepines as a Treatment Option<\/h2>\n<p><span style=\"font-weight: 400;\">Benzodiazepines have been shown to provide relief from anxiety and insomnia in many patients, allowing them to live a higher quality of life. They\u2019re often used for short periods of time, and results can vary by individual, medication, and dosage.<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1536\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2024\/01\/woman-struggling-to-fall-asleep.jpg\" alt=\"woman struggling to fall asleep\" width=\"780\" height=\"521\" \/><\/p>\n<p><span style=\"font-weight: 400;\">However, some medications in this drug class may increase insomnia, worsen anxiety, or create unwanted side effects. The benefits might not always outweigh the risks, so it\u2019s essential to talk openly with your doctor and use benzodiazepines under close supervision.<\/span><\/p>\n<h2>Get the Lowest Price for Your Benzodiazepines<\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking a benzodiazepine, BidRX can help you save money on your prescription. Create a free account, list your medication, and let pharmacies bid for your business. You can accept the offer that fits your budget and have your medications shipped to your door.\u00a0<\/span><\/p>\n<p><b>Find your anxiety medications on our<\/b> <a href=\"https:\/\/www.bidrx.com\/home\/Contents\/medication\"><b>medication page<\/b><\/a> <b>and place your bid today.<\/b><\/p>\n<p><i><span style=\"font-weight: 400;\">This information is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. <\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Learn about benzodiazepines in this comprehensive guide to their subtypes, uses, how they work, potential side effects, warnings, and drug interactions. <\/p>\n","protected":false},"author":2,"featured_media":1532,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[],"class_list":["post-1531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anxiety-medications"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts\/1531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/comments?post=1531"}],"version-history":[{"count":2,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts\/1531\/revisions"}],"predecessor-version":[{"id":1538,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts\/1531\/revisions\/1538"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/media\/1532"}],"wp:attachment":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/media?parent=1531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/categories?post=1531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/tags?post=1531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}