{"id":1105,"date":"2023-07-10T16:53:33","date_gmt":"2023-07-10T16:53:33","guid":{"rendered":"https:\/\/www.bidrx.com\/blog\/?p=1105"},"modified":"2023-09-08T14:39:22","modified_gmt":"2023-09-08T14:39:22","slug":"proton-pump-inhibitors","status":"publish","type":"post","link":"https:\/\/www.bidrx.com\/blog\/acid-reflux-medications\/proton-pump-inhibitors\/","title":{"rendered":"Reference Guide to Proton Pump Inhibitors"},"content":{"rendered":"<p><b>Highlights\u00a0<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Proton pump inhibitors reduce the amount of stomach acid the body produces, helping to improve acid reflux, and conditions caused by long-term stomach acid exposure, such as GERD, ulcers, and erosive esophagitis.<\/b><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Proton pump inhibitors include omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole, and dexlansoprazole.<\/b><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Drug side effects and interactions are similar for all of the PPIs, but there are some differences.\u00a0<\/b><\/li>\n<\/ul>\n<hr \/>\n<p><span style=\"font-weight: 400;\">Proton pump inhibitors (PPIs) are a class of drugs that offer relief for stomach acid-related health issues. Common conditions include gastroesophageal reflux disease (GERD), stomach ulcers, certain types of gastritis, and damage to the esophagus caused by acid reflux. This drug is used to reduce the amount of stomach acid the body produces.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read on to learn more about the different options for proton pump inhibitors and how to find the lowest prices on PPIs.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How Do Proton Pump Inhibitors Work?<\/span><\/h2>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557385\/\"><span style=\"font-weight: 400;\">Proton pump inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> work by blocking the production of stomach acid. This helps to relieve symptoms of <\/span><a href=\"https:\/\/www.bidrx.com\/blog\/acid-reflux-medications\/reference-guide-for-acid-reflux-medications\/\"><span style=\"font-weight: 400;\">acid reflux<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.bidrx.com\/blog\/acid-reflux-medications\/what-is-gastroesophageal-reflux-disease-gerd\/\"><span style=\"font-weight: 400;\">GERD<\/span><\/a><span style=\"font-weight: 400;\">, ulcers, and other stomach acid-related conditions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To do this, PPIs target specific enzymes called proton pumps, which play a role in the final step of stomach acid production. These enzymes are found in the cells of the stomach lining and promote the secretion of gastric acid.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Proton pump inhibitors limit this production and the burstiness of stomach acid. They\u2019re ingested in an inactive form and are activated by the stomach\u2019s acidic environment. The active form of the PPI enters the bloodstream and reaches the parietal cells in the stomach lining. They form a permanent connection with the proton pump enzyme, which is located on the surface of the parietal cells.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">By binding to the proton pump, PPIs stop the secretion of hydrogen ions (or protons) into the stomach, blocking the final step of acid production. The proton pump is responsible for &#8220;pumping&#8221; the protons into the stomach lumen and is unable to do that when bound with the PPI.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As a result, the amount of stomach acid secreted, including any bursts or surges, is drastically reduced. This reduction helps to relieve symptoms and allows the stomach and esophagus to heal.<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1107\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2023\/07\/2.jpeg-6-min.jpg\" alt=\"burstiness of stomach acid\" width=\"780\" height=\"585\" \/><\/p>\n<h2><span style=\"font-weight: 400;\">The Most Commonly Prescribed PPIs\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here\u2019s a closer look at the most commonly prescribed proton pump inhibitors.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Omeprazole<\/span><\/h3>\n<p><a href=\"https:\/\/www.bidrx.com\/home\/ailment_details\/?ailment=Acid%20Reflux&amp;drugName=OMEPRAZOLE\"><span style=\"font-weight: 400;\">Omeprazole<\/span><\/a><span style=\"font-weight: 400;\"> was the first PPI to be introduced. Available as a liquid and a capsule, it\u2019s approved to treat several stomach acid-related conditions, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ulcers in the stomach and small intestine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">GERD<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erosive esophagitis (EE), or inflammation of the esophagus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zollinger-Ellison syndrome<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The brand name for omeprazole is Prilosec. Omeprazole is also available over the counter (Prilosec OTC and Zegerid OTC) and can be used to <\/span><a href=\"https:\/\/www.bidrx.com\/blog\/acid-reflux-medications\/omeprazole\/\"><span style=\"font-weight: 400;\">treat heartburn<\/span><\/a><span style=\"font-weight: 400;\">, although doctors advise using these medications for frequent heartburn only and not for occasional indigestion or heartburn.\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1109\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2023\/07\/3.jpeg-6-min.jpg\" alt=\"Omeprazole box\" width=\"780\" height=\"522\" \/><\/p>\n<h3><span style=\"font-weight: 400;\">Warnings and Contraindications \u2014 Omeprazole\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole can cause kidney problems, so speak with your doctor if you are urinating less frequently or if there is blood in your urine. This drug may also cause diarrhea, which could be a sign of an infection. Let your doctor know immediately if you develop watery stools, fever, or stomach pain.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Omeprazole could cause a serious allergic reaction in patients taking antibiotics for certain conditions. Notify your doctor immediately if you develop trouble breathing or swallowing, swelling of the hands, face, or mouth, or itching.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may also be more prone to bone breakage when taking omeprazole over the long term. This is more common in individuals over the age of 50, if you take high doses of the medication, or if you have been taking the medication for longer than one year.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Omeprazole is a delayed-release drug, so it\u2019s important not to crush, chew, or break the tablets or capsules. Doing so could release all of the medication at once, which may increase your risk of experiencing side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You should also let your doctor know if you have ever had liver disease, lupus, low magnesium, or osteoporosis, or if you are pregnant or breastfeeding.<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539786\/\"><span style=\"font-weight: 400;\">Contraindications<\/span><\/a><span style=\"font-weight: 400;\"> apply to patients who are taking dosage forms of rilpivirine and patients with a history of hypersensitivity to omeprazole or any excipients of its dosage form.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taking this medication may mean having to stop the medication several days prior to certain medical tests or treatments. Make sure your doctor or dentist who treats you knows you are taking this medication.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Side Effects \u2014 Omeprazole\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">PPIs like omeprazole are generally safe for most people. However, like many medications, there can be side effects. Common side effects of omeprazole include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acid reflux<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Less common side effects may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone fracture<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastric polyps<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Appetite loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in taste<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vivid dreams<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chronic inflammation of the stomach<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lowered granulocytes in the blood<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In rare cases, patients may experience:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney inflammation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pancreatitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dermatologic disorder, such as toxic epidermal necrolysis<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Speak with your doctor to learn of other potential side effects or if you experience any new or unusual symptoms after you begin taking this medication.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Drug Interactions \u2014 Omeprazole\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While omeprazole is generally considered safe for most people, several severe reactions have been reported. Severe reactions are rare, but be sure your prescribing physician knows if you are taking any of these medications or supplements:\u00a0<\/span><\/p>\n<p><b>Warfarin: <\/b><span style=\"font-weight: 400;\">Omeprazole can interact with warfarin, an anticoagulant medication used to prevent blood clots. Omeprazole may increase the effects of warfarin, leading to an increased risk of bleeding. Close monitoring of blood clotting parameters is necessary if these medications are taken together.<\/span><\/p>\n<p><b>Methotrexate: <\/b><span style=\"font-weight: 400;\">Omeprazole can also interact with methotrexate, a medication used for cancer, autoimmune diseases, and psoriasis. Omeprazole may increase the concentration of methotrexate, which can lead to an increased risk of side effects. Close monitoring of methotrexate levels and potential toxicities is necessary in this case as well.<\/span><\/p>\n<p><b>Tacrolimus: <\/b><span style=\"font-weight: 400;\">Omeprazole can affect the metabolism of tacrolimus, an immunosuppressant medication used in organ transplantation. This interaction can lead to increased tacrolimus levels, which may increase the risk of side effects. Dose adjustments and careful monitoring are typically required when combining these medications.<\/span><\/p>\n<p><b>Clopidogrel: <\/b><span style=\"font-weight: 400;\">Taking omeprazole with clopidogrel may reduce the effectiveness of clopidogrel in preventing blood clots. This interaction should generally be avoided unless specifically directed by your healthcare provider.<\/span><\/p>\n<p><b>Methotrexate: <\/b><span style=\"font-weight: 400;\">Omeprazole can increase the concentration of methotrexate, a medication used for cancer, autoimmune diseases, and psoriasis. This interaction can lead to increased methotrexate toxicity. Close monitoring of methotrexate levels and potential side effects is necessary if these medications are used together.<\/span><\/p>\n<p><b>Cilostazol: <\/b><span style=\"font-weight: 400;\">Omeprazole can interact with cilostazol, a medication used to treat peripheral vascular disease. This combination may increase the risk of side effects, such as an irregular heartbeat.<\/span><\/p>\n<p><b>St. John&#8217;s Wort: <\/b><span style=\"font-weight: 400;\">Omeprazole can interact with St. John&#8217;s Wort, an herbal supplement used for depression and other conditions. This combination may decrease the effectiveness of omeprazole and potentially lead to inadequate treatment of stomach acid-related conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Less-severe reactions can occur with other medications, as well, including:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Erlotinib<\/b><span style=\"font-weight: 400;\">,\u00a0 drug used for treating cancer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Retrovirals<\/b><span style=\"font-weight: 400;\">, such as nelfinavir and rilpivirine<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These medications should be used with caution. Be sure that each of your medical providers is aware of all the medications and supplements you take.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Esomeprazole<\/span><\/h2>\n<p><a href=\"https:\/\/www.bidrx.com\/home\/ailment_details\/?ailment=Acid%20Reflux&amp;drugName=ESOMEPRAZOLE%20MAGNESIUM\"><span style=\"font-weight: 400;\">Esomeprazole<\/span><\/a><span style=\"font-weight: 400;\"> is a close relative of omeprazole and is considered a more potent form. The brand name of esomeprazole is Nexium, and this medication is used to treat the same conditions as omeprazole. It\u2019s available by prescription and OTC and comes in a delayed-release formula.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Similar to omeprazole, esomeprazole comes in capsule and liquid (esomeprazole magnesium) forms. It\u2019s also available as an injection (esomeprazole sodium), which can only be administered by a hospital.\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1110\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2023\/07\/4.jpeg-3-min.jpg\" alt=\"Esomeprazole bottle\" width=\"780\" height=\"520\" \/><\/p>\n<h3><span style=\"font-weight: 400;\">Warnings and Contraindications \u2014 Esomeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Esomeprazole shares many of the same warnings and precautions as omeprazole.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients with the following conditions should not use this medication:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breathing problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Previous allergic reactions to esomeprazole<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergies to similar medications, such as lansoprazole, omeprazole, pantoprazole, or rabeprazole<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition, esomeprazole could cause symptoms of lupus to worsen. Notify your doctor if you experience joint pain or if you have a skin rash that worsens when exposed to sunlight.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Side Effects \u2014 Esomeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Common side effects may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pains<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Serious side effects may occur when taking esomeprazole. Contact your doctor immediately if you experience any of the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea that\u2019s watery or bloody<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Signs of low magnesium (e.g., dizziness, rapid heart rate, muscle cramps or spasms, jittery feelings, tremors)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or worsening symptoms of lupus<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a complete list of potential side effects. Consult with your doctor for medical advice.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Drug Interactions \u2014 Esomeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many drugs and supplements have been shown to interact with esomeprazole, including but not limited to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cilostazol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diazepam<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Digoxin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erlotinib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ferrous fumarate, ferrous gluconate, ferrous sulfate, and other iron-containing medicines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methotrexate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rifampin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">St. John&#8217;s wort<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tacrolimus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">HIV\/AIDS medications (retrovirals), such as atazanavir, nelfinavir, and saquinavir<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a complete list of drug interactions. Check with your doctor or pharmacist to review your list of medications, vitamins, supplements, and related products.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Lansoprazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Also known as Prevacid, <\/span><a href=\"https:\/\/www.bidrx.com\/home\/ailment_details\/?ailment=Other%20Conditions&amp;drugName=LANSOPRAZOLE\"><span style=\"font-weight: 400;\">lansoprazole<\/span><\/a><span style=\"font-weight: 400;\"> is a PPI that\u2019s available as a prescription or over-the-counter medication. It\u2019s used for similar purposes as omeprazole and esomeprazole but has been shown to have <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9930385\/\"><span style=\"font-weight: 400;\">a faster effect on relieving symptoms<\/span><\/a><span style=\"font-weight: 400;\"> compared to omeprazole. Lansoprazole is available as a prescription and over-the-counter medicine.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Warnings and Contraindications \u2014 Lansoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lansoprazole shares similar warnings and contraindications as omeprazole.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients taking products containing rilpivirine should avoid taking lansoprazole, as it may cause side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Let your doctor know if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a history of liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are pregnant, breastfeeding, or trying to conceive<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are scheduled for an endoscopy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have ever had an allergic reaction to lansoprazole<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Side Effects \u2014 Lansoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Common side effects of lansoprazole are similar to that of other PPIs. If you experience serious side effects, such as joint pain, worsening stomach pain, or bloody stools, contact your doctor immediately.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Drug Interactions \u2014 Lansoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are several known drug interactions with lansoprazole, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atazanavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dasatinib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Delavirdine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indinavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nilotinib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nisoldipine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pazopanib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Phenytoin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ponatinib<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a complete list of drug interactions; <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/lansoprazole-index.html\"><span style=\"font-weight: 400;\">see a complete list of 185 known drug interactions here<\/span><\/a><span style=\"font-weight: 400;\">. Seek additional advice from your healthcare provider.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Rabeprazole<\/span><\/h2>\n<p><a href=\"https:\/\/www.drugs.com\/mtm\/rabeprazole.html\"><span style=\"font-weight: 400;\">Rabeprazole<\/span><\/a><span style=\"font-weight: 400;\"> (also known as AcipHex) is a prescription-only PPI and is used to treat GERD, erosive esophagitis, and gastric ulcers. It is available as a 20 milligram delayed-release tablet and is approved for individuals ages 12 and older. Compared to omeprazole, rabeprazole has been shown to have <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6736539\/\"><span style=\"font-weight: 400;\">a faster and more powerful effect<\/span><\/a><span style=\"font-weight: 400;\"> in reducing gastric acidity.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Warnings and Contraindications \u2014 Rabeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Warnings and contraindications for rabeprazole are similar to those of omeprazole. Consult with your doctor if you have specific concerns.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Side Effects \u2014 Rabeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Rabeprazole side effects may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chills<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yellow eyes and skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapid weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual weight loss or gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dark-colored urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Light-colored stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloating<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">See your doctor immediately if you experience rare side effects, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood in your urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sores in the mouth that won\u2019t heal<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sore throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual bruising or bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual weakness or tiredness<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Drug Interactions \u2014 Rabeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Rabeprazole has moderate interactions with at least 49 drugs and mild interactions with at least 59 different drugs. <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/rabeprazole-index.html\"><span style=\"font-weight: 400;\">See the entire list of drug interactions here<\/span><\/a><span style=\"font-weight: 400;\">. Severe and serious interactions occur with many of the same drugs as other PPIs.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Pantoprazole<\/span><\/h2>\n<p><a href=\"https:\/\/www.bidrx.com\/home\/ailment_details\/?ailment=Acid%20Reflux&amp;drugName=PANTOPRAZOLE%20SODIUM\"><span style=\"font-weight: 400;\">Pantoprazole<\/span><\/a><span style=\"font-weight: 400;\"> (Protonix) is available as a prescription-only medication and is used in a similar manner as other PPIs; however, it is not used to treat or prevent ulcers caused by <\/span><i><span style=\"font-weight: 400;\">H. pylori<\/span><\/i><span style=\"font-weight: 400;\">. It is also approved to treat GERD in children ages 5 and older.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pantoprazole is available as an oral medication that can be taken at home or as an intravenous medication administered by a hospital.<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-1111\" src=\"https:\/\/www.bidrx.com\/blog\/wp-content\/uploads\/2023\/07\/5.jpeg-2-min.jpg\" alt=\"Pantoprazole box\" width=\"780\" height=\"519\" \/><\/p>\n<h3><span style=\"font-weight: 400;\">Warnings and Contraindications \u2014 Pantoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Warning and contraindications for pantoprazole are similar to those of other PPIs. Consult with your doctor about specific concerns.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Side Effects \u2014 Pantoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Side effects when taking pantoprazole are similar to those of other PPIs. Consult with your doctor if symptoms are severe or do not go away.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rare but serious side effects may occur when taking pantoprazole, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in urination frequency<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood in urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash on cheeks or arms that is sensitive to sunlight<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itching<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the eyes, mouth, lips, or face<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blistering or peeling skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flu-like symptoms<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Notify your doctor right away if you experience any of these or other rare side effects.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Drug Interactions \u2014 Pantoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pantoprazole is known to interact with <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/pantoprazole-index.html\"><span style=\"font-weight: 400;\">more than 160 different drugs<\/span><\/a><span style=\"font-weight: 400;\">, including HIV drugs, iron-containing drugs, and others. Many of these interactions also interact with other PPIs. Review your complete list of medications and supplements with your doctor.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Dexlansoprazole<\/span><\/h2>\n<p><a href=\"https:\/\/www.drugs.com\/mtm\/dexlansoprazole.html\"><span style=\"font-weight: 400;\">Dexlansoprazole<\/span><\/a><span style=\"font-weight: 400;\"> is a newer PPI that uses a dual-release mechanism to treat GERD as well as the maintenance and healing of esophagitis. Upon taking the medication, there is an initial release of the medication to limit acid production followed by a delayed release to maintain acid suppression. This medication is approved for use in individuals ages 12 and older.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Warnings and Contraindications \u2014 Dexlansoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Warning and contraindications for dexlansoprazole are similar to those of other PPIs. Consult with your doctor about specific concerns.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Side Effects\u00a0 \u2014 Dexlansoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dexlansoprazole may cause side effects similar to those of other PPIs. In addition, serious side effects similar to those of pantoprazole may also appear.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Drug Interactions \u2014 Dexlansoprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dexlansoprazole interacts with many of the same drugs as other PPIs; 17 of them are considered severe. <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/dexlansoprazole-index.html\"><span style=\"font-weight: 400;\">See the full list of drug interactions here<\/span><\/a><span style=\"font-weight: 400;\">. Review all of the medications and supplements you take with your doctor.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Find the Lowest Price for Proton Pump Inhibitor Medications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Proton pump inhibitors are prescribed for a variety of conditions, including GERD, erosive esophagitis, and Zollinger-Ellison syndrome. No matter your need, there are ways you can save on your prescription medications. BidRX takes the guesswork out of getting the best price. Share the medication you need, and we\u2019ll let reputable pharmacies bid for your business, helping you get the lowest online price and have your medications delivered to you.<\/span><\/p>\n<p><a href=\"https:\/\/www.bidrx.com\/home\/Contents\/how-it-work\"><span style=\"font-weight: 400;\">Get started by creating a bid today<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Proton pump inhibitors (PPIs) are a class of drugs used to treat acid-related digestive disorders like GERD. Here\u2019s what patients should know about taking PPIs.<\/p>\n","protected":false},"author":2,"featured_media":1296,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-1105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-acid-reflux-medications"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts\/1105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/comments?post=1105"}],"version-history":[{"count":1,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts\/1105\/revisions"}],"predecessor-version":[{"id":1112,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/posts\/1105\/revisions\/1112"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/media\/1296"}],"wp:attachment":[{"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/media?parent=1105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/categories?post=1105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bidrx.com\/blog\/wp-json\/wp\/v2\/tags?post=1105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}